Functional mechanisms and potential therapeutic strategies for lactylation in liver diseases
Rong Xu, Yitong Hao, Yahui Liu, Bai Ji, Weibo Tian, Wei Zhang
Abstract
Lactylation, a novel form of lactate-mediated protein post-translational modification (PTM), has been identified as a crucial regulator of gene expression and protein function through the modification of both histone and non-histone proteins. Liver disease is frequently characterized by a reprogramming of glucose metabolism and subsequent lactate accumulation. Recent research has implicated lactylation in a diverse array of hepatic pathologies, including liver injury, non-alcoholic fatty liver disease, liver fibrosis, and hepatocellular carcinoma. Consequently, lactylation has emerged as a pivotal regulatory mechanism in liver disease pathogenesis. This review aims to elucidate the intricate regulatory and functional mechanisms underlying lactylation, synthesize recent advancements in its role in various liver diseases, and highlight its potential as a therapeutic target for future interventions in hepatic disorders. • The regulatory and functional mechanisms of lactylation is comprehensive analyzed. • The mechanistic relevance of lactylation to liver disease pathogenesis is extensively explored. • Potential therapeutic strategies targeting lactylation are discussed.