Extended fluorescent uridine analogues: synthesis, photophysical properties and selective interaction with BSA protein
Ajaykumar V. Ardhapure, Vijay Gayakhe, Shatrughn Bhilare, Anant R. Kapdi, Subhendu Sekhar Bag, Yogesh S. Sanghvi, Krishna Chaitanya Gunturu
Abstract
The improvement in fluorescence properties of 2′-deoxyuridine was made possible by the introduction of (hetero)aromatic moieties at the C–5 position of uridine with alkenyl/phenyl/styryl linkers to create a library of useful fluorescent nucleosides.
Topics & Concepts
ChemistryFluorescenceUridineDeoxyuridineCombinatorial chemistryNucleic acidPhotochemistryStereochemistryRNABiochemistryDNAPhysicsQuantum mechanicsGeneClick Chemistry and ApplicationsDNA and Nucleic Acid ChemistryHIV/AIDS drug development and treatment