The aged extracellular matrix and the profibrotic role of senescence-associated secretory phenotype
Yohannes A. Mebratu, Sourabh Soni, Lorena Rosas, Mauricio Rojas, Jeffrey C. Horowitz, Richard Seonghun Nho
Abstract
Aging is the most prominent nonmodifiable risk factor for various human diseases including Idiopathic pulmonary fibrosis. Aging progressively alters extracellular matrix components and is associated with the accumulation of senescent cells that promote age-related tissue dysfunction. In this review, we will discuss the pathological impact of aging and senescence on lung fibrosis via senescence-associated secretary phenotype factors and potential therapeutic approaches to limit the progression of lung fibrosis.
Topics & Concepts
Extracellular matrixParacrine signallingIdiopathic pulmonary fibrosisFibrosisAutocrine signallingSenescenceCell biologyBiologyPhenotypePulmonary fibrosisImmunologyCancer researchLungPathologyMedicineInternal medicineGeneticsCell cultureReceptorGeneInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisOccupational and environmental lung diseasesTelomeres, Telomerase, and Senescence