Metastatic colorectal cancer cells maintain the TGFβ program and use TGFBI to fuel angiogenesis
Barbara Chiavarina, Brunella Costanza, Roberto Ronca, Arnaud Blomme, Sara Rezzola, Paola Chiodelli, Ambre Giguelay, Guillame Belthier, Gilles Doumont, Gaëtan Van Simaeys, Simon Lacroix, Takehiko Yokobori, Bilguun Erkhem‐Ochir, Patrick Balaguer, Vincent Cavaillès, Eric Fabbrizio, Emmanuel Di Valentin, Stéphanie Gofflot, Olivier Detry, Guy Jérusalem, Serge Goldman, Philippe Delvenne, Akeila Bellahcène, Julie Pannequin, Vincent Castronovo, Andrei Turtoï
Abstract
TGFβ signaling in CRC cells directly contributes to their metastatic potential and stromal cell-independence. Proteins downstream of activated TGFβ, such as TGFBI, represent novel diagnostic and therapeutic targets for more specific anti-metastatic therapies.
Topics & Concepts
TGFBICancer researchEndoglinAngiogenesisMetastasisMedicineCancerColorectal cancerTransforming growth factorBiologyInternal medicineStem cellCell biologyCD34TGF-β signaling in diseasesColorectal Cancer Treatments and StudiesPancreatic and Hepatic Oncology Research