Endoplasmic reticulum stress confers 5-fluorouracil resistance in breast cancer cell <i>via</i> the GRP78/OCT4/lncRNA MIAT/AKT pathway.
Xiaoli Yao, Yi Tu, Yulin Xu, Yueyue Guo, Feng Yao, Xinghua Zhang
Abstract
. These data supported an important role of the ER stress-mediated GRP78/OCT4/lncRNA MIAT/AKT pathway in BC cell resistance to 5-FU, highlighting potential molecular targets for combating 5-FU resistance in BC.
Topics & Concepts
Protein kinase BCancer researchUnfolded protein responsePI3K/AKT/mTOR pathwayEndoplasmic reticulumBiologyChemistrySignal transductionCell biologyEndoplasmic Reticulum Stress and DiseaseAutophagy in Disease and TherapyFerroptosis and cancer prognosis