A Strategy for assessing peak purity of pharmaceutical peptides in reversed-phase chromatography methods using two-dimensional liquid chromatography coupled to mass spectrometry. Part II: Development of second-dimension gradient conditions
Dwight R. Stoll, Maria Sylvester, Melvin R. Euerby, Stephan Buckenmaier, Patrik Petersson
Topics & Concepts
ChemistryChromatographyMass spectrometryPeptideLiquid chromatography–mass spectrometryImpurityReversed-phase chromatographyHigh-performance liquid chromatographyBiochemistryOrganic chemistryAnalytical Chemistry and ChromatographyChromatography in Natural ProductsProtein purification and stability