Neddylation Regulates Macrophages and Implications for Cancer Therapy
Yanyu Jiang, Lihui Li, Li Yan, Guangwei Liu, Robert M. Hoffman, Lijun Jia
Abstract
Tumor-associated macrophages (TAMs) promote cancer progression via stimulating angiogenesis, invasion/metastasis, and suppressing anti-cancer immunity. Targeting TAMs is a potential promising cancer therapeutic strategy. Neddylation adds the ubiquitin-like protein NEDD8 to substrates, and thereby regulates diverse biological processes in multiple cell types, including macrophages. By controlling cellular responses, the neddylation pathway regulates the function, migration, survival, and polarization of macrophages. In the present review we summarized how the neddylation pathway modulates Macrophages and its implications for cancer therapy.
Topics & Concepts
NeddylationNEDD8MacrophageCancerMetastasisUbiquitinAngiogenesisCancer cellCancer researchBiologyMacrophage polarizationCell biologyIn vitroGeneBiochemistryUbiquitin ligaseGeneticsImmune cells in cancerUbiquitin and proteasome pathwaysEpigenetics and DNA Methylation