Reassessing CORM-A1: redox chemistry and idiosyncratic CO-releasing characteristics of the widely used carbon monoxide donor
Nicola Bauer, Xiaoxiao Yang, Zhengnan Yuan, Binghe Wang
Abstract
or high concentrations of buffer. The significant chemical reactivity of CORM-A1 and the highly variable nature of CO release under near-physiological conditions suggest the need for much more consideration of appropriate controls, if available, and caution in using CORM-A1 as a CO surrogate in biological studies.
Topics & Concepts
Carbon monoxideChemistryRedoxOrganic chemistryCatalysisHeme Oxygenase-1 and Carbon MonoxideHemoglobin structure and functionThermal Regulation in Medicine