The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells
Xiaodong Zhuang, Senko Tsukuda, Florian Wrensch, Peter A. C. Wing, Mirjam Schilling, James Michael Harris, Helene Borrmann, Sophie Morgan, Jennifer Cane, Laurent Mailly, Nazia Thakur, Carina Conceicao, Harshmeena Sanghani, Laura Heydmann, C Bach, Anna Ashton, Steven Walsh, Tiong Kit Tan, Lisa Schimanski, Kuan-Ying A. Huang, Catherine Schuster, Koichi Watashi, Timothy Hinks, Aarti Jagannath, Sridhar R. Vausdevan, Dalan Bailey, Thomas F. Baumert, Jane A. McKeating
Abstract
silencing induced interferon-stimulated gene transcripts in Calu-3 lung epithelial cells, providing a mechanism for the circadian pathway to limit SARS-CoV-2 infection. Our study highlights alternative approaches to understand and improve therapeutic targeting of SARS-CoV-2.
Topics & Concepts
Circadian clockCircadian rhythmReplication (statistics)BiologyCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Cell biology2019-20 coronavirus outbreakNeuroscienceVirologyMedicineInfectious disease (medical specialty)Internal medicineOutbreakDiseaseCircadian rhythm and melatoninDietary Effects on HealthImmune responses and vaccinations