SPOP mutations promote p62/SQSTM1-dependent autophagy and Nrf2 activation in prostate cancer
Qing Shi, Xiaofeng Jin, Pingzhao Zhang, Qian Li, Zeheng Lv, Yan Ding, Huiying He, Yijun Wang, Yuanlong He, Xiaying Zhao, Shi-Min Zhao, Yao Li, Kun Gao, Chenji Wang
Topics & Concepts
AutophagyUbiquitin ligaseUbiquitinKEAP1CarcinogenesisSignal transducing adaptor proteinBAG3Cell biologyBiologyCancer researchMutantUbiquitin-Protein LigasesULK1Deubiquitinating enzymeMutationSignal transductionScaffold proteinChemistryHEK 293 cellsProstate cancerMdm2ATG16L1KinaseProteostasisGeneCytoplasmUbiquitin-conjugating enzymeTranscription factorReceptorAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseaseRedox biology and oxidative stress