Azelaic Acid: Mechanisms of Action and Clinical Applications
Xiaoyue Feng, J. Shang, Zhengping Gu, Junhua Gong, Yong Chen, Youting Liu
Abstract
AZA is a non-phenolic, saturated dicarboxylic acid with nine carbon atoms, naturally produced by the yeast Malassezia. It has diverse physiological activities, including antibacterial, anti-keratinizing, antimelanogenic, antioxidant and anti-inflammatory effects. AZA is widely used in dermatology and is FDA-approved for treating papulopustular rosacea. It also shows significant efficacy in acne vulgaris and melasma. This review summarizes the mechanisms of action and clinical applications of AZA, aiming to provide theoretical support for its clinical and cosmetic use and to facilitate further research.
Topics & Concepts
Azelaic acidMedicineAction (physics)DermatologyBiochemistryBiologyPhysicsQuantum mechanicsAcne and Rosacea Treatments and EffectsEssential Oils and Antimicrobial ActivityPhytochemistry and Bioactivity Studies