VCAM-1 mediates proximal tubule-immune cell cross talk in failed tubule recovery during AKI-to-CKD transition
Isabel Melchinger, Kailin Guo, Xiaoxu Li, Jian-Kan Guo, Lloyd G. Cantley, Leyuan Xu
Abstract
We demonstrated the induction of VCAM-1 and its biological function in proximal tubules. We found that proinflammatory cytokines (TNF-α and IL-1β) significantly induced VCAM-1 expression via NF-κB signaling pathway. TNF-α treatment or overexpression of VCAM-1 in immortalized MPT cells increased CD45 + splenocyte adhesion. Pharmacological inhibition of NF-κB or genetic deletion of Vcam1 suppressed TNF-α-induced splenocyte adhesion in vitro, suggesting that VCAM-1 mediates proximal tubular-immune cell cross talk in failed tubule recovery during AKI-to-CKD transition.
Topics & Concepts
Proinflammatory cytokineAcute kidney injuryKidneyCell biologyCancer researchTumor necrosis factor alphaKidney diseaseBiologyInflammationMedicineInternal medicineImmunologyEndocrinologyAcute Kidney Injury ResearchRenal and related cancersChronic Kidney Disease and Diabetes