Experimental and theoretical studies of the rhodium(<scp>i</scp>)-catalysed C–H oxidative alkenylation/cyclization of<i>N</i>-(2-(methylthio)phenyl)benzamides with maleimides
Aymen Skhiri, Attila Táborosi, Nozomi Ohara, Yusuke Ano, Seiji Mori, Naoto Chatani
Abstract
We presented the synthesis of isoindolone spirosuccinimides via the Rh( i )-catalysed reaction of aromatic amides that contain a (2-methylthio)aniline directing group with maleimides. Several possible reaction paths were examined by DFT calculations.
Topics & Concepts
ChemistryAnilineRhodiumOxidative phosphorylationMedicinal chemistryStereochemistryOrganic chemistryCatalysisBiochemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms