Glucuronidation of Methylated Quercetin Derivatives: Chemical and Biochemical Approaches
Maite L. Docampo Palacios, Anislay Alvarez‐Hernandez, Olubu A Adiji, Daylín Gamiotea Turro, Alexander B. Valerino-Díaz, Luı́s P. Viegas, Ikenna E. Ndukwe, Ângelo de Fátima, Christian Heiß, Parastoo Azadi, Giulio Maria Pasinetti, Richard A. Dixon
Abstract
was synthesized in five steps at 34% overall yield. A mechanistic study on the unexpected regioselectivity observed in the quercetin glucuronide synthetic steps is also presented.
Topics & Concepts
QuercetinGlucuronidationChemistryGlucuronideYield (engineering)Chemical synthesisRegioselectivityBiochemistryStereochemistryEnzymeMetabolismAntioxidantIn vitroMicrosomeCatalysisMaterials scienceMetallurgyCarbohydrate Chemistry and SynthesisPlant Gene Expression AnalysisPhytochemicals and Antioxidant Activities