LncRNA AC099850.3 promotes hepatocellular carcinoma proliferation and invasion through PRR11/PI3K/AKT axis and is associated with patients prognosis
Fang-Jing Zhong, Sheng Liu, Donghai Hu, Liwen Chen
Abstract
Background: LncRNA is a key factor influencing tumor development. The present study aimed to investigate the effect of a novel lncRNA on the progression of hepatocellular carcinoma (HCC). Methods: A candidate lncRNA in The Cancer Genome Atlas database was identified using limma and survival R packages. The effect of lncRNA AC099850.3 on cell proliferation, apoptosis, migration, and invasion, as well as its association with immune cells in HCC were investigated. Furthermore, the functional mechanisms of lncRNA AC099850.3 in HCC were elucidated.
Topics & Concepts
Cancer researchPI3K/AKT/mTOR pathwayGene knockdownHepatocellular carcinomaBiologyProtein kinase BOncogeneImmune systemCell growthCellApoptosisCD8ImmunologyCell cycleBiochemistryGeneticsCancer-related molecular mechanisms researchRNA modifications and cancer