Microglia exosomal miRNA-137 attenuates ischemic brain injury through targeting Notch1
Dianquan Zhang, Guoliang Cai, Kai Liu, Zhe Zhuang, Kunping Jia, Siying Pei, Xiuzhen Wang, Hong Wang, Shengnan Xu, Cheng Cui, Manchao Sun, Sihui Guo, Wenli Song, Guofeng Cai
Abstract
. BV2-Exo also decreased infarct volume and behavioral deficits in ischemic mice. Exosomal miRNA-137 was upregulated in BV2-Exo and participated in the partial neuroprotective effect of BV2-Exo. Furthermore, Notch1 was a directly targeting gene of exosomal miRNA-137. In conclusion, these results suggest that BV2-Exo alleviates ischemia-reperfusion brain injury through transporting exosomal miRNA-137. This study provides novel insight into microglial exosomes-based therapies for the treatment of ischemic brain injury.
Topics & Concepts
MicrogliamicroRNAMicrovesiclesExosomeNeuroscienceMedicineChemistryInflammationBiologyImmunologyGeneBiochemistryMicroRNA in disease regulationExtracellular vesicles in diseaseNeuroinflammation and Neurodegeneration Mechanisms