<i>Vitreoscilla</i>hemoglobin: a natural carbene transfer catalyst for diastereo- and enantioselective synthesis of nitrile-substituted cyclopropanes
Hanqing Xie, Fengxi Li, Yaning Xu, Chunyu Wang, Yuelin Xu, Junhao Wu, Zhengqiang Li, Zhi Wang, Lei Wang
Abstract
we developed an environmentally friendly strategy that combines in situ generation of a diazo reagent with biocatalysis for the asymmetric cyclopropanation of olefins.
Topics & Concepts
CyclopropanationEnantioselective synthesisNitrileDiazoCarbeneChemistryCatalysisReagentOrganic chemistryCombinatorial chemistryBiocatalysisReaction mechanismCyclopropane Reaction MechanismsAsymmetric Hydrogenation and Catalysis