“Naked Nickel”-Catalyzed Amination of Heteroaryl Bromides
Rakan Saeb, Bryan Boulenger, Josep Cornellà
Abstract
High Resolution Image Download MS PowerPoint Slide In this Letter, we report that the air-stable “naked nickel” [Ni( 4- t Bu stb) 3 ] is a competent catalyst in thermal C–N bond formation between (hetero)aryl bromides and N -based nucleophiles. The catalytic system is characterized by a “naked nickel” complex and Zn and by the absence of external light sources, photocatalysts, exogenous ligands, and electrical setups. Upon application of this method, various heteroaryls bearing Lewis-basic heteroatoms can be accommodated and directly aminated with a set of primary and secondary amines.
Topics & Concepts
ChemistryAminationCatalysisNickelCombinatorial chemistryOrganic chemistryMedicinal chemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis