Lactate metabolism coordinates macrophage response and regeneration in zebrafish
Candice Bohaud, Jholy De La Cruz, Claudia Terraza, Audrey Barthelaix, Béryl Laplace-Builhe, Christian Jørgensen, Yoan Arribat, Farida Djouad
Abstract
Altogether, our findings highlight the crucial role of lactate at the onset of macrophage differentiation toward a pro-inflammatory phenotype. The deep modifications of macrophage phenotype mediated by lactate and downstream effectors play a key role to coordinate inflammatory response and tissue regeneration.
Topics & Concepts
Cell biologyZebrafishMacrophage polarizationBiologyTranscriptomeRegeneration (biology)MacrophageGlycolysisGene expressionBiochemistryMetabolismGeneIn vitroImmune cells in cancerZebrafish Biomedical Research ApplicationsEpigenetics and DNA Methylation