Diminishing hERG inhibitory activity of aminopiperidine-naphthyridine linked NBTI antibacterials by structural and physicochemical optimizations
Maja Kokot, Matjaž Weiss, Irena Zdovc, Marko Anderluh, Martina Hrast, Nikola Minovski
Topics & Concepts
hERGDNA gyraseChemistryTopoisomeraseLinkerTopoisomerase IVEscherichia coliTopoisomerase inhibitorBiochemistryAntibacterial activityPharmacologyDNABacteriaBiophysicsBiologyGeneGeneticsPotassium channelOperating systemComputer scienceCancer therapeutics and mechanismsAntibiotics Pharmacokinetics and EfficacyAntibiotic Resistance in Bacteria