Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis
Jun‐Bin He, Lian Wu, Wanqing Wei, Song Meng, Zhengtao Liu, Xuan Wu, Hai‐Xue Pan, Sheng Yang, Yong Liang, Jiahai Zhou, Gong‐Li Tang
Topics & Concepts
Ring (chemistry)ChemistryNucleophileEpoxideIntramolecular forceTetrahydrofuranBiosynthesisStereochemistryHydrogen bondEnzymeCombinatorial chemistryCatalysisMoleculeOrganic chemistrySolventMicrobial Natural Products and BiosynthesisCarbohydrate Chemistry and SynthesisSynthetic Organic Chemistry Methods