Chromosome-Level Genome Assembly of a Human Fungal Pathogen Reveals Synteny among Geographically Distinct Species
Mark Voorhies, Shirli Cohen, Terrance Shea, Semar Petrus, José F. Muñoz, Shane G. Poplawski, William E. Goldman, Todd P. Michael, Christina A. Cuomo, Anita Sil, Sinem Beyhan
Abstract
strains using long-read sequencing technology. Comparative analysis of these genomes shows largely conserved gene order within the chromosomes. Mapping existing transcriptome data on these new assemblies reveals clustering of transcriptionally coregulated genes. The results of this study highlight the importance of obtaining chromosome-level assemblies in understanding the biology of human fungal pathogens.
Topics & Concepts
BiologySyntenyGenomeHistoplasmaGeneticsNanopore sequencingComparative genomicsGenomicsEvolutionary biologyGeneHistoplasma capsulatumHistoplasmosisImmunologyFungal Infections and StudiesAntifungal resistance and susceptibilityPlant Pathogens and Fungal Diseases