Litcius/Paper detail

Tuning Activity and Selectivity during Alkyne Activation by Gold(I)/Platinum(0) Frustrated Lewis Pairs

Nereida Hidalgo, Juan J. Moreno, Marina Pérez‐Jiménez, Celia Maya, Joaquín López‐Serrano, Jesús Campos

2020Organometallics36 citationsDOIOpen Access PDF

Abstract

Introducing transition metals into frustrated Lewis pair systems has attracted considerable attention in recent years. Here we report a selection of three metal-only frustrated systems based on Au(I)/Pt(0) combinations and their reactivity toward alkynes. We have inspected the activation of acetylene and phenylacetylene. The gold(I) fragments are stabilized by three bulky phosphines bearing terphenyl groups. We have observed that subtle modifications on the substituents of these ligands proved critical in controlling the regioselectivity of acetylene activation and the product distribution resulting from C(sp)-H cleavage of phenylacetylene. A mechanistic picture based on experimental observations and computational analysis is provided. As a result of the cooperative action of the two metals of the frustrated pairs, several uncommon heterobimetallic structures have been characterized.

Topics & Concepts

ChemistryFrustrated Lewis pairAlkyneSelectivityPlatinumLewis acids and basesStereochemistryMedicinal chemistryCombinatorial chemistryCatalysisOrganic chemistryOrganoboron and organosilicon chemistryOrganometallic Complex Synthesis and CatalysisCatalytic Cross-Coupling Reactions