Induction of Apoptosis in Cancer Cells by Glutathione Transferase Inhibitor Mediated Hydrophobic Tagging Molecules
Xiaona Li, Zirui Lü, Cong Wang, Kebin Li, Fengrong Xu, Ping Xu, Yan Niu
Abstract
The abnormally high expression of glutathione transferases is closely associated with cancer incidence and drug resistance. By introducing a hydrophobic moiety to the inhibitor structure, we organized a series of degraders of glutathione transferases and demonstrated them potently inducing apoptosis in cancer cells, presenting their pharmacological potential in cancer therapy.
Topics & Concepts
GlutathioneApoptosisCancer cellGlutathione transferaseCancerChemistryGlutathione S-transferaseCancer researchDrug resistanceBiochemistryMoietyTransferaseEnzymeBiologyStereochemistryGeneticsGlutathione Transferases and PolymorphismsGenomics, phytochemicals, and oxidative stressEstrogen and related hormone effects