High-Voltage Electrical Pulses in Oncology: Irreversible Electroporation, Electrochemotherapy, Gene Electrotransfer, Electrofusion, and Electroimmunotherapy
Bart Geboers, Hester J. Scheffer, Philip M. Graybill, Alette H. Ruarus, Sanne Nieuwenhuizen, Robbert S. Puijk, M. Petrousjka van den Tol, Rafael V. Davalos, Boris Rubinsky, Tanja D. de Gruijl, Damijan Miklavčič, Martijn R. Meijerink
Abstract
. Additional electroporation-based technologies that may reach clinical importance, such as gene electrotransfer, electrofusion, and electroimmunotherapy, are concisely reviewed. HVEPs represent a substantial advancement in cancer research, and continued improvement and implementation of these presented technologies will require close collaboration between engineers, interventional radiologists, medical oncologists, and immuno-oncologists.
Topics & Concepts
ElectrochemotherapyElectroporationMedicineIrreversible electroporationElectrofusionCancer researchMembrane permeabilityPharmacologyInternal medicineChemotherapyMembraneBiologyGeneBleomycinGeneticsBiochemistryMetallurgyMaterials scienceMicrobial Inactivation MethodsPulsed Power Technology ApplicationsMicrofluidic and Bio-sensing Technologies