Glytabastan B, a coumestan isolated from Glycine tabacina, alleviated synovial inflammation, osteoclastogenesis and collagen-induced arthritis through inhibiting MAPK and PI3K/AKT pathways
Yanbei Tu, Lihua Tan, Tao Lu, Kai Wang, Haiyong Wang, Bing Han, Yuxin Zhao, Hanbin Chen, Yanfang Li, Haixia Chen, Meiwan Chen, Chengwei He
Topics & Concepts
MAPK/ERK pathwayChemistryMatrix metalloproteinaseArthritisPharmacologyInflammationRheumatoid arthritisOsteoclastLY294002PI3K/AKT/mTOR pathwayMechanism of actionGlycineSignal transductionCancer researchCell biologyDownregulation and upregulationReceptorDrugImmunologyBlockadeBiochemistryNF-κBInflammatory arthritisEnzymeBone Metabolism and DiseasesBioactive natural compoundsNatural product bioactivities and synthesis