Genome-Scale Analysis of Acetobacterium woodii Identifies Translational Regulation of Acetogenesis
Jongoh Shin, Yoseb Song, Seulgi Kang, Sangrak Jin, Jung-Kul Lee, Dong Rip Kim, Suhyung Cho, Volker Müller, Byung‐Kwan Cho
Abstract
during the gas fermentation process. We found that the methyl and carbonyl branches of the Wood-Ljungdahl pathway are activated at similar translation levels during autotrophic growth. Translation is mainly regulated by the 5'-untranslated-region structure and ribosome-binding-site sequence. This work reveals novel translational regulation for coping with autotrophic growth conditions and provides the systematic data set, including the transcriptome, translatome, and promoter/5'-untranslated-region bioparts.
Topics & Concepts
AcetogenesisComputational biologyTranslation (biology)ChemistryBacteriaBiochemistryBiologyMessenger RNAGeneticsGeneMethanogenesisMicrobial Metabolic Engineering and BioproductionGenomics and Phylogenetic StudiesRNA and protein synthesis mechanisms