New Vistas for Cell-Surface GlycoRNAs
Sigrid Nachtergaele, Yamuna Krishnan
Abstract
Discoveries in noncoding RNA have shown it to be remarkably diverse in function and form and to have relevance in drug development. A recent study showed that some noncoding RNAs are glycosylated and sialylated and expressed on the surface of the plasma membrane. Moreover, some interact with Siglec-15, an immune suppressor that is up-regulated in human cancer cells and tumor-infiltrating myeloid cells.
Topics & Concepts
Immune systemMedicineCell biologyRNAMyeloid cellsFunction (biology)SuppressorCellMyeloidLong non-coding RNAImmunologyCancerGeneCancer researchComputational biologyBiologyGeneticsInternal medicineRNA modifications and cancerCancer-related molecular mechanisms researchGalectins and Cancer Biology