Poly-l-lysine derivative-coated black phosphorus as a nanoplatform for photothermal chemotherapy to enhance anti-tumor efficiency
Anning Li, Siqi Wang, Zhiqiang Zhang, Na Xu, Guixia Ling, Peng Zhang
Abstract
experiments showed that the combination of biomaterial (PLL) and photothermal material (BP nanosheets) exhibited excellent biological safety and remarkable drug delivery capacity. Moreover, the pharmacodynamic studies indicated that PLL-SS@DOX-BP is a powerful vehicle for photothermal therapy in combination with chemotherapy. Compared with chemotherapy alone, the developed DDS displayed enhanced anti-tumor efficiency with decreased systemic toxicity, and thus, it has the potential to be a promising anti-tumor treatment strategy.
Topics & Concepts
Black phosphorusPhotothermal therapyMaterials scienceLysineDerivative (finance)PhosphorusChemotherapyNanotechnologyCancer researchOptoelectronicsChemistryBiochemistryMedicineInternal medicineMetallurgyFinancial economicsEconomicsAmino acidNanoplatforms for cancer theranosticsExtracellular vesicles in disease2D Materials and Applications