Boiling histotripsy and in-situ CD40 stimulation improve the checkpoint blockade therapy of poorly immunogenic tumors
Mohit Pratap Singh, Sri Nandhini Sethuraman, Craig Miller, Jerry R. Malayer, Ashish Ranjan
Abstract
Data suggest that HT40 reprograms immunologically cold tumors and sensitizes them to ICI therapy. This approach may be clinically useful for treating advanced stage melanoma cancers.
Topics & Concepts
CD8Tumor microenvironmentCancer researchPopulationMedicineImmune checkpointGranzyme BImmune systemImmunotherapyMelanomaImmunologyEnvironmental healthCancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesNanoplatforms for cancer theranostics