Rational design of ROS-responsive nanocarriers for targeted X-ray-induced photodynamic therapy and cascaded chemotherapy of intracranial glioblastoma
Beibei Zhang, Rui Xue, Chunyang Sun
Abstract
Targeted T- TK NP VP consisting of ROS-responsive thioketal linkers realized transcranial X-PDT and X-ray-activated chemotherapy for locoregional glioblastoma treatment in vivo .
Topics & Concepts
NanocarriersPhotodynamic therapyPaclitaxelCancer researchVerteporfinTranscytosisChemotherapyPhotosensitizerReactive oxygen speciesChemistryPharmacologyMedicineDrugReceptorInternal medicineBiochemistryChoroidal neovascularizationEndocytosisOrganic chemistryRetinalNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryPhotodynamic Therapy Research Studies