α,α′-C–H Bond Difunctionalization of Unprotected Alicyclic Amines
Daniel A. Valles, Subhradeep Dutta, Anirudra Paul, Khalil A. Abboud, Ion Ghiviriga, Daniel Seidel
Abstract
A simple one-pot procedure enables the sequential, regioselective, and diastereoselective introduction of the same or two different substituents to the α- and α'-positions of unprotected azacycles. Aryl, alkyl, and alkenyl substituents are introduced via their corresponding organolithium compounds. The scope of this transformation includes pyrrolidines, piperidines, azepanes, and piperazines.
Topics & Concepts
Alicyclic compoundChemistryCyclic aminesBondCombinatorial chemistryMedicinal chemistryOrganic chemistryAmine gas treatingBusinessFinanceCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsRadical Photochemical Reactions