Design and biological evaluation of cinnamic and phenylpropionic amide derivatives as novel dual inhibitors of HIV-1 protease and reverse transcriptase
Mei Zhu, Qi Shan, Ling Ma, Jiajia Wen, Biao Dong, Guoning Zhang, Minghua Wang, Juxian Wang, Jinming Zhou, Shan Cen, Yucheng Wang
Topics & Concepts
ChemistryHIV-1 proteaseStereochemistrySteric effectsCoumarinIC50Reverse transcriptaseEnzymeEnzyme inhibitorProteaseHuman immunodeficiency virus (HIV)PotencyLigand (biochemistry)Combinatorial chemistryBiochemistryIn vitroVirologyReceptorOrganic chemistryGeneBiologyRNAHIV/AIDS drug development and treatmentHIV Research and TreatmentHIV/AIDS Research and Interventions