<i>De novo</i> synthesis of inherently chiral heteracalix[4]aromatics from enantioselective macrocyclization enabled by chiral phosphoric acid-catalyzed intramolecular S<sub>N</sub>Ar reaction
Xingchi Li, Ying Cheng, Xudong Wang, Shuo Tong, Mei‐Xiang Wang
Abstract
,O-calix[2]arene[2]triazines from enantioselective macrocyclization enabled by chiral phosphoric acid-catalyzed intramolecular nucleophilic aromatic substitution reaction. In contrast to documented examples, the inherent chirality of the acquired compounds arises from one heteroatom difference in the linking positions of heteracalix[4](het)arenes.
Topics & Concepts
Intramolecular forceEnantioselective synthesisChemistryCatalysisHeteroatomPhosphoric acidChirality (physics)StereochemistryCombinatorial chemistryMedicinal chemistryOrganic chemistryNambu–Jona-Lasinio modelQuarkPhysicsQuantum mechanicsRing (chemistry)Chiral symmetry breakingSupramolecular Chemistry and ComplexesMolecular Sensors and Ion DetectionPorphyrin and Phthalocyanine Chemistry