Phosphite–imidazole catalyzed <i>N</i>-formylation and <i>N</i>-acylation of amines
Babak Kaboudin, Hesam Esfandiari, Meysam Kakavand, Masoumeh Sohrabi, Elahe Yousefian Amirkhiz, Abdollah Neshat, Teru Kawazoe, Haruhiko Fukaya, Hikaru Yanai
Abstract
The N -formylation reaction of amines with DMF as a formylating agent was developed. N -Sulfonyl amidines were also obtained in good to excellent yields by the reaction of sulfonamides with DMF under similar conditions.
Topics & Concepts
ChemistryFormylationCatalysisImidazoleNucleophileAcylationOrganic chemistrySubstrate (aquarium)SulfonylReaction conditionsAcetylationMedicinal chemistryCombinatorial chemistryGeologyAlkylBiochemistryOceanographyGeneChemical Synthesis and AnalysisCarbon dioxide utilization in catalysisAsymmetric Hydrogenation and Catalysis