Synthesis of novel coumarin–hydrazone hybrids as α-glucosidase inhibitors and their molecular docking studies
Hafiza Zara Tariq, Aamer Saeed, Saeed Ullah, Noor Fatima, Sobia Ahsan Halim, Ajmal Khan, Hesham R. El‐Seedi, Muhammad Zaman Ashraf, Muhammad Latif, Ahmed Al‐Harrasi
Abstract
analysis reflects that hydrazone moiety is an essential pharmacophore for the binding of compounds with the active site residues of the enzyme. This study demonstrates that compounds 7c and 7f deserve further molecular optimization for potential application in diabetic management.
Topics & Concepts
CoumarinHydrazoneDocking (animal)In silicoChemistryCombinatorial chemistryStereochemistryComputational biologyBiochemistryOrganic chemistryBiologyMedicineGeneNursingNatural Antidiabetic Agents StudiesCarbohydrate Chemistry and SynthesisEnzyme Catalysis and Immobilization