Harnessing the effects of hypoxia-like inhibition on homology-directed DNA repair
Gary Altwerger, Maddie Ghazarian, Peter M. Glazer
Topics & Concepts
Synthetic lethalityPoly ADP ribose polymeraseDNA repairDownregulation and upregulationCancer researchPARP inhibitorImmunotherapyPopulationDNA damageHypoxia (environmental)PharmacologyBiologyMedicinePolymeraseDNAImmunologyChemistryImmune systemGeneticsGeneEnvironmental healthOxygenOrganic chemistryPARP inhibition in cancer therapyDNA Repair MechanismsAutophagy in Disease and Therapy