<i>Wolbachia</i> and Virus Alter the Host Transcriptome at the Interface of Nucleotide Metabolism Pathways
Amelia R. I. Lindsey, Tamanash Bhattacharya, Richard W. Hardy, Irene L. G. Newton
Abstract
Recently developed arbovirus control strategies leverage the symbiotic bacterium Wolbachia , which spreads in insect populations and blocks viruses from replicating. While this strategy has been successful, details of how this “pathogen blocking” works are limited. Here, we use a combination of virus infections, fly genetics, and transcriptomics to show that Wolbachia and virus interact at host nucleotide metabolism pathways.
Topics & Concepts
WolbachiaBiologyTranscriptomeHost (biology)ArbovirusVirusPathogenComputational biologyVirologyGeneticsGeneGene expressionInsect symbiosis and bacterial influencesMosquito-borne diseases and controlInsect and Pesticide Research