Perspective on Proteomics for Virus Detection in Clinical Samples
Marica Grossegesse, Felix Hartkopf, Andreas Nitsche, Lars Schaade, Joerg Doellinger, Thilo Muth
Abstract
One of the most widely used methods to detect an acute viral infection in clinical specimens is diagnostic real-time polymerase chain reaction. However, because of the COVID-19 pandemic, mass-spectrometry-based proteomics is currently being discussed as a potential diagnostic method for viral infections. Because proteomics is not yet applied in routine virus diagnostics, here we discuss its potential to detect viral infections. Apart from theoretical considerations, the current status and technical limitations are considered. Finally, the challenges that have to be overcome to establish proteomics in routine virus diagnostics are highlighted.
Topics & Concepts
ProteomicsComputational biologyVirusMolecular diagnosticsPandemicCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VirologyBiologyBioinformaticsMedicineDiseasePathologyInfectious disease (medical specialty)BiochemistryGeneAdvanced Proteomics Techniques and ApplicationsBiosensors and Analytical DetectionSARS-CoV-2 detection and testing