Elevated serum TARC levels precede classic Hodgkin lymphoma diagnosis by several years
Arjan Diepstra, Ilja M. Nolte, Anke van den Berg, Larry Magpantay, Otoniel Martı́nez-Maza, Lynn I. Levin
Abstract
Tumor cells in classic Hodgkin lymphoma produce high quantities of the thymus- and activation-related chemokine (TARC). We measured TARC levels in prediagnostic serum samples and found strikingly increased values in the vast majority of patients, as early as 6 years before diagnosis.
Topics & Concepts
Hodgkin lymphomaLymphomaChemokineMedicineInternal medicineImmunologyCancer researchInflammationLymphoma Diagnosis and TreatmentImmune Cell Function and InteractionChronic Lymphocytic Leukemia Research