Regulation of HPV E7 Stability by E6-Associated Protein (E6AP)
Arushi Vats, Óscar Trejo-Cerro, Paola Massimi, Lawrence Banks
Abstract
This is the first demonstration that E6AP can directly help stabilize the HPV E7 oncoprotein, in a manner similar to that observed with HPV E6. This redefines how E6 and E7 can cooperate and potentially modulate each other's activity and further highlights the essential role played by E6AP in the viral life cycle and malignancy.
Topics & Concepts
Ubiquitin ligaseBiologyUbiquitinProteasomeCell biologyEctopic expressionGene knockdownCarcinogenesisProteolysisCell cultureCancer researchCancerBiochemistryEnzymeGeneticsGeneViral-associated cancers and disordersCervical Cancer and HPV ResearchVirus-based gene therapy research