Progress and assessment of lncRNA DGCR5 in malignant phenotype and immune infiltration of human cancers.
Chen Xue, Can Chen, Xinyu Gu, Lanjuan Li
Abstract
expression is related to many hallmarks of cancer types, including cell proliferation, invasion, migration, apoptosis, stemness, and therapeutic responsiveness. Additionally, the pivotal molecules involved in DGCR5 regulation of signaling pathways are attributed to cancer hallmarks related to the pathogenesis of different types of malignant tumors. Herein, we discuss the DGCR5 expression pattern in various types of tumor tissues and relationships between DGCR5 expression and immune cell infiltration and immune purity. We also review our current understanding of DGCR5 in carcinogenesis and its potential application as a prognostic biomarker or therapeutic target in human cancers.
Topics & Concepts
Cancer researchCarcinogenesisImmune systemBiologyCancerBreast cancerLong non-coding RNAGeneImmunologyRNAGeneticsCancer-related molecular mechanisms researchRNA modifications and cancerCircular RNAs in diseases