Heterologous biosynthesis of prenylated resveratrol through multiplex metabolic engineering in <i>Escherichia coli</i>
Haijiao Wang, Ting Zhou, Hui Liu, Lingrong Wen, Yueming Jiang, Bao Yang
Abstract
2-C-Prenyl resveratrol was successfully produced by reconstructing the MVA pathway, resveratrol synthesis pathway and metabolic flux engineering to accumulate acetyl-CoA and malonyl-CoA.
Topics & Concepts
ResveratrolPrenylationMetabolic engineeringBiosynthesisHeterologousFlux (metallurgy)ChemistryBiochemistryMetabolic pathwayEscherichia coliHeterologous expressionMetabolismEnzymeGeneOrganic chemistryRecombinant DNASirtuins and Resveratrol in MedicineMicrobial Metabolic Engineering and BioproductionPlant biochemistry and biosynthesis