Structure-based discovery of SIAIS001 as an oral bioavailability ALK degrader constructed from Alectinib
Chaowei Ren, Ning Sun, Ying Kong, Xiaojuan Qu, Haixia Liu, Hui Zhong, Xiaoling Song, Xiaobao Yang, Biao Jiang
Topics & Concepts
AlectinibAnaplastic lymphoma kinaseChemistryALK inhibitorBioavailabilityCancer researchCereblonAnaplastic large-cell lymphomaPharmacologyUbiquitin ligaseLymphomaLung cancerBiochemistryUbiquitinBiologyGeneMalignant pleural effusionInternal medicineImmunologyMedicineProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments