The Mechanism of Kidney Disease Due to APOL1 Risk Variants
Etienne Pays
Abstract
The apoL1 C-terminal variants G1 and G2 are linked to CKD.[1][1] Expression of these variants induces effacement of podocyte foot processes, leading to the loss of these cells from glomeruli and impairment of the blood filtration activity of the kidney. A characteristic of G1/G2-linked disease is
Topics & Concepts
PodocyteKidney diseaseMechanism (biology)DiseaseKidneyRenal functionMedicineBiologyInternal medicineEndocrinologyCell biologyPathologyProteinuriaEpistemologyPhilosophyRenal Diseases and GlomerulopathiesBiomedical Research and PathophysiologyGenetic Syndromes and Imprinting