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Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses

Ruyu Wang, Guanglei Zhai, Guanghao Zhu, Mengge Wang, Xiaoyi Gong, Weidong Zhang, Guang‐Bo Ge, Hongzhuan Chen, Lili Chen

2022Bioorganic Chemistry12 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryProteasesIC50CoronavirusEnzymeProteaseCysteine proteaseActive siteDocking (animal)DrugMechanism of actionBiochemistryDrug discoveryStereochemistryPharmacologyIn vitroCoronavirus disease 2019 (COVID-19)BiologyInfectious disease (medical specialty)PathologyDiseaseNursingMedicineSARS-CoV-2 and COVID-19 ResearchComputational Drug Discovery MethodsCOVID-19 Clinical Research Studies
Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses | Litcius