The STAT1/HMGB1/NF-κB pathway in chronic inflammation and kidney injury after cisplatin exposure
Ying Fu, Xiang Yu, Ying Wang, Zhiwen Liu, Danyi Yang, Jie Zha, Chengyuan Tang, Juan Cai, Guochun Chen, Zheng Dong
Abstract
These results unravel the STAT1/HMGB1/NF-κB pathway that contributes to persistent inflammation and chronic kidney problems after cisplatin nephrotoxicity, suggesting new therapeutic targets for kidney protection in cancer patients receiving cisplatin chemotherapy.
Topics & Concepts
Gene knockdownHMGB1Cancer researchSTAT1KidneyNephrotoxicityMedicineFibrosisInflammationChemistryPathologyImmunologyInternal medicineApoptosisInterferonBiochemistryChemotherapy-induced organ toxicity mitigationAcute Kidney Injury ResearchChronic Kidney Disease and Diabetes