The Effects of Ketogenic Diet on Insulin Sensitivity and Weight Loss, Which Came First: The Chicken or the Egg?
Antonio Paoli, Antonino Bianco, Tatiana Moro, João Felipe Mota, Christianne de Faria Coelho‐Ravagnani
Abstract
The ketogenic diet (KD) is, nowadays, considered an interesting nutritional approach for weight loss and improvement in insulin resistance. Nevertheless, most of the studies available in the literature do not allow a clear distinction between its effects on insulin sensitivity per se, and the effects of weight loss induced by KDs on insulin sensitivity. In this review, we discuss the scientific evidence on the direct and weight loss mediated effects of KDs on glycemic status in humans, describing the KD's biochemical background and the underlying mechanisms.
Topics & Concepts
Ketogenic dietWeight lossInsulin sensitivityEndocrinologyInternal medicineMedicineInsulinBiologyInsulin resistanceObesityEpilepsyPsychiatryDiet and metabolism studiesDiet, Metabolism, and DiseaseAdipose Tissue and Metabolism