Selenium deficiency causes immune damage by activating the DUSP1/NF-κB pathway and endoplasmic reticulum stress in chicken spleen
Yiming Zhang, Liu Qingqing, Yin Hang, Min Yahong, Shu Li
Abstract
transport, leading to endoplasmic reticulum stress (ERS). Moreover, we determined that Se deficiency triggered the low expression of DUSP1/NF-κB. In summary, our results indicate that Se deficiency can inhibit the spleen immune function of chickens by regulating the DUSP1/NF-κB pathway and ERS, leading to spleen damage in chickens. Based on transcriptomics research, our results will help further study the harmful effects of Se deficiency.
Topics & Concepts
Endoplasmic reticulumSpleenImmune systemUnfolded protein responseSelenium deficiencySeleniumHomeostasisCell biologyBiologyLymphocyteChemistryEndocrinologyImmunologyInternal medicineOxidative stressMedicineGlutathione peroxidaseCatalaseOrganic chemistrySelenium in Biological SystemsEndoplasmic Reticulum Stress and DiseaseLiver Disease Diagnosis and Treatment