A cerium oxide-based nanomedicine for pH-triggered chemodynamic/chemo combination therapy
Ying Chen, Jiahui Zan, Yong Liu, Peipei Kuang, Chunmei Guo, Chen Xie, Wei Huang, Quli Fan
Abstract
) can be selectively catalyzed into highly toxic hydroxyl radicals (˙OH) under acidic conditions by DOX@PCMNR-RGD, showing CDT activity. Meanwhile, the acidic condition can trigger the release of DOX, showing chemotherapeutic activity. Thus, our study provides a pH-triggered chemodynamic/chemo combination therapeutic nanoplatform with minimal side effects.
Topics & Concepts
Cerium oxideNanomedicineCeriumOxideMaterials scienceChemistryNanotechnologyInorganic chemistryNanoparticleMetallurgyAdvanced Nanomaterials in CatalysisNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranostics